Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning
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Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning.
A series of polyvinylpyrrolidone fibers loaded with paracetamol (PCM) and caffeine (CAF) was fabricated by electrospinning and explored as potential oral fast-dissolving films. The fibers take the form of uniform cylinders with smooth surfaces, and contain the drugs in the amorphous form. Drug-polymer intermolecular interactions were evidenced by infrared spectroscopy and molecular modeling. Th...
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The volatility and limited water solubility of linalool is a critical issue to be solved. Here, we demonstrated the electrospinning of polymer-free nanofibrous webs of cyclodextrin/linalool-inclusion complex (CD/linalool-IC-NFs). Three types of modified cyclodextrin (HPβCD, MβCD, and HPγCD) were used to electrospin CD/linalool-IC-NFs. Free-standing CD/linalool-IC-NFs facilitate maximum loading ...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2014
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2014.10.036